Preimplantation genetic screening using comprehensive chromosome screening: evidence and remaining challenges

Preimplantation genetic screening using comprehensive chromosome screening: evidence and remaining challenges.

Sir, We read with great interest a recent systematic review by Lee et al. published inyour journal evaluating the clinical effectivenessofpreimplantation genetic diagnosis for aneuploidy in all 24 chromosomes (PGD-A) (Lee et al., 2015). The authors conclude that, for the time being, the role for PGD-A remains uncertain regarding its clinicaland costeffectiveness. In our opinion, a number of obs...

I-20: Towards The Transparent Embryo: Dynamics and Ethics of Comprehensive Preimplantation Genetic Screening

Background: To study the ethical aspects of comprehensive preimplantation genetic screening (PGS) through microarrays and whole genome sequencing Materials and Methods: In order to pinpoint ethical issues regarding comprehensive embryo screening we have first investigated the technical and moral issues by organizing a campus meeting with experts and by a literature study. Subsequently we have i...

Preimplantation genetic screening.

Preimplantation Genetic Screening

In the last 30 years, genetic testing techniques have been developed to identify chromosomally normal embryos in vitro, thereby potentially increasing the proportion of successful cycles with elective single-embryo transfer, and minimizing twin-pregnancy complications and miscarriages. This testing is termed "pre-implantation genetic screening" (PGS), in contrast to preimplantation genetic diag...

Technical Update: Preimplantation Genetic Diagnosis and Screening.

OBJECTIVE To update and review the techniques and indications of preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS). OPTIONS Discussion about the genetic and technical aspects of preimplantation reproductive techniques, particularly those using new cytogenetic technologies and embryo-stage biopsy. OUTCOMES Clinical outcomes of reproductive techniques followi...